You WILL have to run some type of rise rate regulator even with larger injectors. Running 450s and a 1:1 AFPR is not going to cut it. If you run larger injectors you will either have to turn down the base pressure or use some type of fuel controller to compensate for them.

I had good luck running a SFMU along with some 310cc injectors. Also upgraded to 440s and ran up with 18psi once the motor was built

98 Eclipse GS Turbo
Built motor - MS2 - Holset hy35 - Zoom Stg 4 Clutch - 57.5mm TB - ARP Headstuds - Turbonetics wastegate - 3" Turbo back - FMIC - Greddy RZ BOV - Walbro 255 - 650cc Injectors - Fidanza Flywheel - Cobra calipers w/ 13" Rotors - Oil Cooler - DevilsOwn meth injection

1981 Chevy Scottsdale
1987 Nissan 300zx - Chump Car
2001 BMW 325i