I'm running 225/50R16's on 3rd-gen Rx7 rims (16x8), which isn't the size you're asking about... but my single contribution to this thread will be: it depends if a.) you're lowered, b.) how much, and c.) with CORRECT camber (camber kits front & rear). You may fit @ stock height and/or with bad camber.
Me personally, I actually had to cut the entire lip of rear fenders off w/ dremel, and change spacers from 15mm down to 5mm (I think those are the sizes)... when I got my alignment that is. I'm on Tokico Illuminas, Eibach springs, with Front & Rear Ingalls Camber Correction kits... and my Eclipse is settled very low indeed.
Me and speed bumps don't get along as I scrape/bottom-out my undercarraige. Another sad fact: I can also tell when my tires drop below 30lbs, as I start scraping the speed bumps pretty good in my neighborhood.
