most of the drag race domestic guys run low comp pistons in their nitrous motors, but there are some guys who run tiny smallblocks with high comp pistons and nitrous and make huge power spinning a lot of rpm, and I think that is more relevant for a motor like ours... but they both have completely different schools of thought. the big motor, low comp guys just get torque monsters while the small motor guys spin a lot of rpm, which is basically what import guys have to do.
either way, with a strong bottom end and careful tuning, you could get a hell of a lot of power out of a direct port system. the limitation isn't so much your cylinder head and pistons, but what you can do with your fuel delivery and tuning. a stand-alone engine management would be a very important part of a build-up like this.