Maybe screw with your accel/decel enrich, otherwise I just leaned the crap out of the lower VE bins at high RPM to keep it from loading, because they really don't see normal driving operation anyway. Otherwise you're goin to get some knock, no matter what you do, just because of wall-wetting and all that good stuff that there will be some extra fuel. Just as long as it's only a few it shouldn't really hurt anything.